e familiar with 一般是指某人熟悉某人、某物:
例句:
I'm not familiar with this computer.我不熟悉这台电脑.
Oh,at the end some songs that everyone's familiar with,then they can join in.噢,在晚会快要结束时来几首大家都熟悉的歌曲,那样听众就可以跟着唱.
be familiar to 则是某物、某事为某人所熟悉:
例句:
The name seems familiar to me 相当于I seem familiar with the name.这个名字我似乎是很熟悉的.