D issue
issue 作为问题是表示的是比较正式重大的问题,强调的是正式
question就是指一些学习上的生活上的具体问题,也可以说是难题
stuff表示的是某某之类的琐事
matter表示重大的事,麻烦的事儿
Medical care reform has became this country's most important
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