1、regardless是副词,而despite是介词,所以 ...so one carried on regardless 是正确的表达,而 despite 不能这样使用,毕竟词性不同嘛.
2、但 regardless 可与 of 形成固定搭配并当作介词使用,所以 you insist on putting it regardless of regular rules.而 despite = in spite of,因此,不能与 of 搭配使用.
3、regardless of 常使用 how,what,why 即 w- 系引导的从句,而despite 通常接名词或名词性短语,当然再来个同位语从句也行,如 ...despite the fact that ...,较少使用what之类的名词性从句.
4、despite可以接反身代词,而regardless (of) 却不能.所以,Almost despite himself,as he jumped into the terribly cold river to save the drowning boy.但是 He ever jumped into the river for saving life of a boy,regardless (regardless of ...).却也不错啥.
其它的,一时半会也想不起来了哈.