I didn't get to the station until about 9:30,by which time the train had already left.
The train had already left by the time I got to the station.
从上面例句可以看到
by which time 需要一个具体的/特定的时间范围,而
by the time 仅表示一个抽象的(非特定)时间
(比如,对第二句听者可以追问:and what time was that?)