1.I don't know how to do with it.我不知道用它如何做.
2.I don't know what to do with it.我不知道如何处理它
"如何处理":how ...和deal with搭配 或 ..what和 do with 搭配
"处理"deal with = do with
I don't know how to make it.口语 我不知如何完成它.
4.I don't know what to make it 错句 应是 I don't know what to make .
I don't know how to do it.
我不知如何做它.