可以有两种说法·
however serious a problem you may have..
或者whatever a serious problem you may have
很简单的让步状语跟感叹句的混合
你可以这么想 你有个多么严重的问题啊
可以这么翻译·：how serious a problem you have!
或者 what a serious problem you have !
现在加上让步状语
就是把how 和what 写成however和 whatever.
恩恩···就是这样