e responsibie for 对……负责任,是从任务本身或道德层面上说的,如
He should be responsible for that.
他应该对此事负有责任.
Everyone should be responsible for his work.
每个人都应对自己的工作负责.
We should be responsible for the generation as yet unborn.
我们应该对下一代负责.
in charge of 管理,负责,是指负责某一件具体的事或管理公司等
You're responsible to whoever is in charge of sales.
你要向主管销售的人负责.
I am in charge of financial affairs.
我职掌财务.