1 What's wrong with you?/what's the matter with you?你怎么了?
2 You should go to hospital.你应该去看病.
3 What's the matter?或者What's the trouble?怎么了?
4 How is it going today?今天一切怎么样?
5 How often should you take the medicine?
three times a day 一天三次,表示频率,要用how often(多久一次),来提问,再接上一般疑问句“should you take the medicine three times a day?”