= -(a+5b-2c)(a+5b+8c)
= -[(a+5b)-2c][(a+5b)+8c]
= -[(a+5b)^2+16c(a+5b)-4c(5b+a)-16c^2]
= -[a^2+10ab+25b^2+16ac+80cb-20bc-4ac-16c^2]
= -[a^2+25b^2-16c^2+10ab+12ac+60bc]
= -a^2-25b^2+16c^2-10ab-12ac-60bc
= -(a+5b-2c)(a+5b+8c)
= -[(a+5b)-2c][(a+5b)+8c]
= -[(a+5b)^2+16c(a+5b)-4c(5b+a)-16c^2]
= -[a^2+10ab+25b^2+16ac+80cb-20bc-4ac-16c^2]
= -[a^2+25b^2-16c^2+10ab+12ac+60bc]
= -a^2-25b^2+16c^2-10ab-12ac-60bc