However huge the difficulty is,we can overcome it as long as we have a steel will,
No matter how huge the difficulty is,we can overcome it as long as we have a steel will,
这里的however应该是无论怎样,无论如何的意思,跟no matter how应该是通用的,但是这里我个人认为no matter how 可能会合适一些,读起来会更通顺.