A.isn't为正确选项
当must表示猜测,“一定.”的意思时,反义疑问句的简略句的助动词要根据实际的动词来决定.本句的实际动词为系动词 is.故简略句要用isn't it?在（主语something 相当于 it）
Something must be wrong with your watch,___?反义疑问句
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