可以,这里的does和is都是一般疑问句,并且is在这里并不是一楼说的反义疑问句.但be doing sth.也可表将来,不过放在这里的语境中就不一定通了,所以这里的is和dose都表一般现在时,应该可以换成does.
-Is Mr .Smith working this week?-No,he is on holiday.能改成Does
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