答:have taken place.
注意,这个问题十分阴险,因为很容易让人产生误导而填成被动式have been taken place,其实不然,英语中”发生变化”：take place是不用被动语态的,就是直接变成过去式或过去分词就可以了．
18.Great changes ___ (take place),and a lot of factories hav
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