It makes people feel （加that 引导宾语从句）there is no hope （exists 去掉） and there is no use of making any efforts （加 to do sth 固定搭配,要带宾语） .
that 不能省,它是引导的两个并列句,省得就不和下面一个there is并列了
It makes people feel that there is .and there is .
make efforts to do sth 努力做某事