应该是一样的.你看例句就知：
At supper,everyone was in high spirits.
晚餐时,每个人都兴致勃勃.
来自柯林斯例句
John is in high spirits at the prospects.约翰对前景充满希望.来自《简明英汉词典》
In this fresh spring morning,we rushed out in a high spirit.在这种新的春天早晨,我们赶到了一个高精神.
但如表示【纯一人】的情况还是用in a high spirit 较好.