D
选D。题干的意思是：“________一定的数学知识，认真研究物理是不可能的。”against“靠着；反对”；before“在……之前”；beyond“超出”；without“没有”。四个选项中填入without最合适，故选D。
(2013·高考新课标全国卷Ⅱ)A serious study of physics is impossible____
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