不可以,a lot of既可以修饰可数名词复数,又可以修饰不可数名词,而 a number of只能修饰可数名词复数,在本句中shopping 已经具有抽象的名词作用,表示购物这个动作,不能用a number of修饰.
I did a lot of christmas shopping.a lot of 可以改成 a number of
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