应该选B
解析：
不定式to instruct it____you want it to do 是作为effective communication 的主语补足语出现的,____you want it to do 是介词连接的一个宾语从句,分析句子成分可知do后面缺少宾语（名词性）,而选项中只有what可以作为宾语使用.about是构成介宾短语的介词修饰it的.
do是一个及物动词,后面必须跟宾语,故不能选D
When raining a dog,effective communication is necessay to in
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翻译It is raining cats and dogs!