人生总有不如意时
There is a crook in the lot of every one
[参考词典]：汉英综合大词典
人生麻烦事,接连不断来
life is one damn thing after another;
life is one damned thing after another
[参考词典]：汉英综合大词典
Not everything can go on as one wishes in one's whole life
No perfect life
shit happens
参考资料：出自《friends》