它是当然可以,一定,务必的意思,相当于我们很熟悉的certainly,of course,当然,如果我们学会更丰富的英语表达,您的口语听上去不是更地道吗?我们听听下面的小对话：
B:By all means.没问题,交给我了.
B:I’ll make it by all means.我一定去接你.
就可以到了.issue是个名词,是问题,议题; 争论点的意思,如果我有些不满,我就可以说：I have some issues.意思是我有些意见,有些不满.
I have some issues with my boss lately.我最近对我的老板有些意见.
Janet has some issues with her parents.珍丽对她的父母有些情绪.
如果你对某事有看法,不满,可以在have some issues后加个介词on或者about,
She has some issues on her new job.她对她的新工作不太满意.