是强调句型，应该用that的。
逗号后面的限定词不能用that是指非限定性定语从句，这里并非定语从句，不受其限制。
例句：
It is
Asia, with its huge population at risk, that will have the biggest impact on the
global spread of AIDS.
高考英语 单项选择 It was with the first aid of a local guide and a h
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